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Exposure of human lung epithelial (A549) cells to acrolein (150 fmol/cell for 1 h) first depleted 80% of the intracellular GSH pool and then increased the transcription of -glutamylcysteine synthetase at 6-12 h post-treatment, resulting in normalization of GSH levels

Additionally, by validation in an independent second patient cohort (n=156), we successfully replicated the high-performance predictions for F0/F1 and F3/F4 fibrosis stages with an AUC of 0.84

Piperine, a functional food alkaloid, exhibits inhibitory potential against TNBSinduced colitis via the inhibition of IB-/NF-B and induces tight junction protein (claudin-1, occludin, and ZO-1) signaling pathway in experimental mice

Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: A role for ifn-gamma

Although the exact cause of melasma remains unknown, several factors are recognized as potential triggers

2-Hydroxylated and 4-hydroxylated estrogen exerts biologic responses on the cyclic secretion of leutenising hormone (LH) perhaps even on follicle stimulating hormone (FSH) and prolactin